New hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds
One of the major problem in biomedicine technologies is nontoxic nanomaterials for drug storage and delivery. The limiting characteristics of existing materials are low efficiency loading (about 5 mass percent) and fast drug realize. Porous MOF-based hybrid nanomaterials have a possibility of fine tuning of structure and properties. The later is a result of a wide variety of organic linkers and metal clusters that compose the framework structure. Biomedical applications of metal-organic frameworks is a novel trend that develops at a record breaking pace. The later resulting in the number of original research papers[1-6] and fundamental reviews[7-9].
Such hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds have been synthesized. The periodic structure have been studied by means of X-ray diffraction. Local atomic and electronic structure have been studied by means of element specific X-ray Absorption Spectroscopy. FTIR-spectroscopy has been used to monitor the adsorption of guest molecules inside pores. Biological activity have been studied in non pathogenic bacteria.
 P. Horcajada et.al. Nature Materials 9 (2010) p172
 A.C. McKinlay et.al. JACS 130 (2008) p10440
 L. Xing et.al. ChemCommun 48 (2012) 5995
 P. Horcajada et.al. Angew. Chem. Int. Ed. 45 (2006) 5974
 C. Tamames-Tabar et.al. CrystEngComm 17 (2015) 456
 J. Rabone et.al. Science 329 (2010) 1053
 F. Novio et.al. Coordination Chemistry Reviews 257 (2013) 2839
 P. Horcajada et.al.Chem. Rev. 112 (2012) 1232
 I. Imaz et.al. ChemComm 47 (2011) 7287