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New hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds

Name
Mikhail
Surname
Soldatov
Scientific organization
Southern Federal University
Academic degree
PhD
Position
Leading researcher
Scientific discipline
Physics & Astronomy
Topic
New hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds
Abstract
Hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds have been synthesized. The periodic structure have been studied by means of X-ray diffraction. Local atomic and electronic structure have been studied by means of element specific X-ray Absorption Spectroscopy. FTIR-spectroscopy has been used to monitor the adsorption of guest molecules inside pores.
Keywords
hybrid nanomaterials, bioactive materials, Metal-organic frameworks
Summary

One of the major problem in biomedicine technologies is nontoxic nanomaterials for drug storage and delivery. The limiting characteristics of existing materials are low efficiency loading (about 5 mass percent) and fast drug realize. Porous MOF-based hybrid nanomaterials have a possibility of fine tuning of structure and properties. The later is a result of a wide variety of organic linkers and metal clusters that compose the framework structure. Biomedical applications of metal-organic frameworks is a novel trend that develops at a record breaking pace. The later resulting in the number of original research papers[1-6] and fundamental reviews[7-9]. 

Such hybrid MOF-based nanomaterials for storage and delivery of bioactive compounds have been synthesized. The periodic structure have been studied by means of X-ray diffraction. Local atomic and electronic structure have been studied by means of element specific X-ray Absorption Spectroscopy. FTIR-spectroscopy has been used to monitor the adsorption of guest molecules inside pores. Biological activity have been studied in non pathogenic bacteria.
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