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MULTIFUNCTIONAL NANOSTRUCTURED CARRIERS WITH CONTROLLABLE SENSITIVITY TO ULTRASOUND FOR THERANOSTICS

Name
Dmitry
Surname
Gorin
Scientific organization
Saratov State University
Academic degree
Dr
Position
Professor
Scientific discipline
Chemistry & Chemical technologies
Topic
MULTIFUNCTIONAL NANOSTRUCTURED CARRIERS WITH CONTROLLABLE SENSITIVITY TO ULTRASOUND FOR THERANOSTICS
Abstract
New type of drug delivery carriers that will combine some functions as in vivo navigation and visualization, sensing of important biological marker, remote release of bioactive substances by external influences has a good perspective for applications in biomedicine. It was demonstrated that by control of nano- and microarchitecture of prepared surface, core-shell structures and capsule and also by variation of surface hydrophobicity, volume fraction and chemical composition of polyelectrolyte and inorganic nanoparticles can be change a sensitivity of carriers to ultrasound.
Keywords
nanostructured carrires,drug delivery, sensitivity to ultrasound, remote release, theranostics
Summary

Theranostics defines the unique technologies that combine both medical diagnostics and therapeutics. Magnetite nanoparticles are a nice example of theranostic objects that can be used as MRI contrast agents and carrier for hypothermia induced by alternating magnetic fields. Other directions of theranostics are connected with nanostructured carrier applications. The Layer by Layer assembly technique is a power tool for creation of nanostructured multifunctional carriers combined sensing and drug delivery [1]. It was demonstrated that the sensitivity of capsule and core-shell to external influences as laser irradiation [2], magnetic field [2], ultrasound treatment [3] can be changed by variation of volume fraction and chemical composition of inorganic nanoparticles in the polyelectrolyte/nanoparticle shell. Same approach is applied for theranostic carrier visualization by MRI [4] and photoacoustic method [5] using magnetite and gold nanoparticles as contrast agents, respectively. Recently, it was shown the possibility to create a nanostructured SERS platform based on core-shell and capsules decorated by gold nanoparticles for studies of the chemical composition inside living cells [6]. This new type of object can be named satellite that can be used for studies of the microworld inside living organisms and their treatment on the cellular level and also for monitoring of implant/tissue interfaces [6].

The most important aspect is obtaining sensitivity of objects to external influences including ultrasound for remote release of bioactive substances realization. It was demonstrated that by control of nano- and microarchitecture of prepared surface, core-shell structures and capsule and also by variation of surface hydrophobicity, volume fraction and chemical composition of polyelectrolyte and inorganic nanoparticles can be change a sensitivity of prepared objects to ultrasound.

Obtained results are very important for creation of new generation of drug delivery systems including drug depot, combined much functionality as navigation and visualization, in vivo monitoring of biochemical process, remote activated release of bioactive substances in vivo by ultrasound.

References

[1] Stetciura, I.Y.; Markin, A.V.; Bratashov, D.N.; Sukhorukov, G.B.; Gorin, D.A.: Current Opinion in Pharmacology, 2014, 18, 149

[2] Gorin, D.A; Portnov, S.A; O.A. Inozemtseva, O.A.; Luklinska Z.; Yashchenok, A.M.; Pavlov, A.M.; Skirtach, A.G.; Möhwald, H.; Sukhorukov, G.B.: Phys. Chem. Chem. Phys., 2008, 10, 6899

[3] Korolovych, V.F.; Grishina, O.A.; Inozemtseva, O.A.; Selifonov, A.V.; Bratashov, D.N.; S.G. Suchkov, S.G.;  Bulavin, L.A.;  Glukhova, O.E.;  Sukhorukov, G.B.; Gorin D.A.: Phys. Chem. Chem. Phys., 2016, 18, 2389

[4] German, S.V.; Navolokin, N.A.; Kuznetsova, N.R.; Zuev, V.V.; Inozemtseva, O.A.; Anis’kov, A.A.; Volkova, E.K.; Bucharskaya,  A.B.; Maslyakova, G.N.; Fakhrullin, R.F.; Terentyuk, G.S.; E.L. Vodovozova, E.L.; Gorin, D.A.: Colloids and Surfaces B, 2015, 135,109

[5] Yashchenok, A. M.; Jose, J.; Trochet, P.; Sukhorukov, G.B.; Gorin, D.A.: Journal of Biophotonics, 2016, 1–8, DOI10.1002/jbio.201500293  

[6] Stetciura, I.Y.; Yashchenok, A.; Masic,A; Lyubin, E.V.; Inozemtseva, O.A.; Drozdova, M.G.; Markvichova, E. A.; Khlebtsov, B.N.; Fedyanin, A.A.; Sukhorukov, G.B.; Gorin, D.A.; Volodkin, D.: Analyst, 2015, 140, 4981