Identification of antagonists of psoriasis-associated IL-36 cytokine activation
Scientific organizationSaint Petersburg Institute of Technology
Scientific disciplineLife Sciences & Medicine
TopicIdentification of antagonists of psoriasis-associated IL-36 cytokine activation
IL-36α, IL-36β and IL-36γ, have been implicated as key initiators of psoriatic-type skin inflammation. IL-36 cytokines are expressed as inactive precursors and require proteolytic processing for activation. We have developed a panel of peptide-based inhibitors of cathepsin G and elastase, based on optimal cleavage motifs, which can antagonize activation of all three IL-36 family members by the latter proteases. Inhibitors of neutrophil-derived proteases, as reported herein, may have therapeutic utility through blocking activation of IL-36 family cytokines in psoriasis.
KeywordsInflammation, proteases, proteolysis, neutrophils