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healthcare and sanocreatology

Scientific organization
Institute of Fundamental Medicine and Biology
Academic degree
Professor, DSci, honorary member of Republic of Tatarstan Academy of Sciences
chief scientist
Scientific discipline
Life Sciences & Medicine
healthcare and sanocreatology
Title: Resilience to orthostasis and haemorrhage: A study of common genetic and conditioning mechanisms
The objective of this study was to examine acquired and innate vagal mechanisms that protect against physical challenges and haemorrhages. These include examining change in heart rate variability in response to orthostatic challenge, platelet count (PLT), mean platelet volume, and single-nucleotide polymorphisms in genes. Regular physical training of athletes indirectly modifies the genetic predisposing effects of some haemostatic factors on vagal tone and reactivity.
genetic predisposition, heart rate variability, haemostasis system at athlets and non-athlets

Abstract in full:

A major challenge presently is not only to identify the genetic polymorphisms increasing risk to diseases, but to also find out factors and mechanisms, which can counteract a risk genotype by developing a resilient phenotype. The objective of this study was to examine acquired and innate vagal mechanisms that protect against physical challenges and haemorrhages in 19 athletes and 61 non-athletes. These include examining change in heart rate variability (HF-HRV; an indicator of vagus
activity) in response to orthostatic challenge, platelet count (PLT), mean platelet volume (MPV), and single-nucleotide polymorphisms in genes that encode several coagulation factors, PAI-1, and MTHFR. Individual differences in PLT and MPV were significant predictors, with opposite effects, of the profiles of the HF-HRV changes in response to orthostasis. Regular physical training of athletes indirectly (through MPV) modifies the genetic predisposing effects of some haemostatic factors (PAI-1 and MTHFR) on vagal tone and reactivity. Individual differences in vagal tone were also associated with relationships between Factor 12 C46T and Factor 11 C22771T genes polymorphisms.
This study showed that genetic predispositions for coagulation are modifiable. Its potential significance is promoting advanced protection against haemorrhages in a variety of traumas and injuries, especially in individuals with coagulation deficits.


Professor Dr. Renad Zhdanov’s List of selected publications 2016-2014:

h-index = 14 - thе data are extracted from the Web of Science® and reproduced under a license from Thomson Reuters):  http://expertcorps.ru/science/whoiswho/info/45496   (Google Academia: 1652 citations, h-index 18 https://scholar.google.com/citations?user=myAUGaMAAAAJ&hl=ru )

Zhdanov R.I., Doinikova A.N., Jdanova S.I., Chernokhvostov Yu.S., Gadzhieva E.I., Dvoenosov V.G. Correlation between haemostatic and vegetate nervous system parameters under examination stress // Neuroscience and Behavioral Physiology. Springer. 2016. Vol. 46, № 3 . IF 0,400 (in press) as a translation of the published paper: Жданов Р.И., А.Н. Дойникова, С.И. Жданова, Ю.В. Чернохвостов и Э.С.Гаджиева, В.Г. Двоеносов. Корреляция параметров системы гемостаза и вегетативной нервной системы при экзаменационном стрессе // Журнал Высшей Нервной Деятельности им. И.П. Павлова. IF 0,400 – 2016. – Т. 66, № 2. – С. 202-208.

Zolyan S.T., Zhdanov R.I. Genome as a (hyper)text: from metaphor to theory // Sign Systems Studies (Tartu) (Scopus). 2016 (accepted; in press).

Zhdanov R.I., D. Kern, W. Lorenz, M.Ya. Ibragimova. Fatty acid and lipid profile of Pseudomonas aurantiaca DNA-bound lipids according mass-spectrometry data // Microbiology (Moscow) Int. Ed. 2015. – Vol. 84, № 1. – P. 34-40. DOI: 10.1134/S0026261714060228 - IF 0.350

Davydov D.M., Zhdanov R.I., Dvoenosov V.G., Kravtsova O.A., Voronina E.N., Filipenko M.L.. Resilience to orthostasis and hemorrhage: Common effects of some genetic and conditioning factors // Sci. Reports Nature PG. 2015. V. 5, article number № 10703. DOI:10.1038/srep10703. – IF 5,578

Tuktamyshov R.N., Zhdanov R.I. The method of in vivo evaluation of haemostasis: Spatial thrombodynamics // Hemаtology. 2015. Vol. 20, № 10, 584-586. - IF 1,253 DOI: http://dx.doi.org/10.1179/1607845415Y.0000000022

Nurbekov M.K., A.A. Elov, A.B. Il’in, M.Y. Ibragimova, R.I. Zhdanov

Tryptophanyl-tRNA synthase gene expression as genetic marker of the athletes’ overtraining // Geny I Kletki = Genes and Cells. 2015. – Vol X, # 3 (in Russian).

Krylov A.S., Zhdanov R.I. Nucleic acid-protein identification: novel protein classification based on nucleic acid-protein interaction // Geny I Kletki = Genes and Cells. 2015. Vol X, # 1 (in Russian) (http://genescells.ru/arhiv/tom-x-2015-1)

Zhdanov Renad, Eric C. Schirmer, Anuroop V. Venkatasubramani, Alastair R. W. Kerr, Elena Mandrou, Giovanny Rodriguez-Blanco, and Alexander Kagansky (2015). Lipids contribute to epigenetic control via chromatin structure and functions. ScienceOpen Research. 2015. V. 10 (15), article number 3127 (DOI: 10.14293/S2199-1006.1.SOR-LIFE.AUXYTR.v1)

R.I. Zhdanov, and M.Y. Ibragimova. Linking genomics and lipidomics: chromatin-bound lipids as a language of genome, Book of Abstracts, Future of Biomedicine 2015 Conference, FEFU School of Biomedicine, September 2-7 2015, Vladivostok, Russia (http://fob.su/left-menu/fob-2015-program/)

Kupriyanov R.V., Zhdanov R.I. The eustress concept: problems and outlooks // World J. Med. Sci. – 2014. – V. 11, № 2. – P. 179-185.

Zhdanov R.I., Chardonnet P. Russian stamp issued to honour physicist. Nature (London). – 2014. - V. 512 (№ 7513), 136 (August 14, 2014).

And 12 articles in Scopus Journals in Russian.