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Impact of interferon system on Paramyxovirus-mediated oncolysis.

Name
Irina
Surname
Sivova
Scientific organization
engelhardt institute of molecular biology russian academy of sciences
Academic degree
no
Position
student
Scientific discipline
Life Sciences & Medicine
Topic
Impact of interferon system on Paramyxovirus-mediated oncolysis.
Abstract
Oncolytic virotherapy is a new progressive approach of anticancer therapy. Oncolytic viruses naturally replicate preferentially in cancer cells leading to killing tumor cells without harming normal tissue.
Mitochondrial antiviral-signaling protein (MAVS), is an important key molecule involved in host defense and promotes a signal for producing type I IFN. Here we demonstrated the correlation between sensitivity cancer cell line to paramyxoviruses action and cancer cells MAVS expression level.
Keywords
oncolytic virus, cancer therapy
Summary

Oncolytic virotherapy is a new progressive approach of anticancer therapy. Oncolytic viruses naturally replicate preferentially in cancer cells leading to killing tumor cells without harming normal tissue. Paramyxoviruses are thought to be an advanced oncolytic virus family which also can stimulate immune system effectively. Interactions between innate and adaptive immune cells and signaling factors (i.e., cytokines and chemokines), often involved in virus infections, play a large role in antitumor immunity. 

Mitochondrial antiviral-signaling protein (MAVS), also called IPS-1/VISA/Cardif, is an important key molecule involved in host defense and promotes a signal for producing type I IFN. Here we demonstrated the correlation between sensitivity cancer cell line to paramyxoviruses action and cancer cells MAVS expression level.

We tested the wide panel of cancer cell lines to define its sensitivity to paramyxovirus action. We established that cancer cell lines possess different sensitivity to Sendai viruses which is invert correlated with basic level of MAVS expression. Moreover, silencing of the endogenous MAVS expression by RNAi lead to significant increasing cancer cells sensitivity to paramyxovirus action.