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Genomics of brain functions and brain pathologies

Name
Evgeny
Surname
Rogaev
Scientific organization
Center of Brain Neurobiology and Neurogenetics, The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
Academic degree
Professor, Dr.Sci, Member of Academia Europaea
Position
Head of the Center of Brain Neurobiology and Neurogenetics
Scientific discipline
Life Sciences & Medicine
Topic
Genomics of brain functions and brain pathologies
Abstract
No
Keywords
genetics, epigenetics, neuropsychiatric diseases, behavioral traits
Summary

We applied new generation sequencing (NGS) technologies to track the genetic and epigenetic alterations underlying common and rare neuropsychiatric diseases and behavioral traits. In this presentation the methodologies for the whole genome sequencing and epigenome or transcriptome analysis will be summarized for (i) identification of mutant gene linked to impairment of human-specific phenotype (bipedal locomotion, intellect and speech) inherited as monogenic trait in human pedigree ; (ii) tracking open chromatin alterations in cortical neurons in cohort of schizophrenic patients versus controls; (iii) identification of genetic variants and gene neuro-net pathways in Alzheimer’s disease; (iii) identification of genetic variations in behavioral farm-lab animal models selected for tame and aggressive behavior.