Defects in antiviral signaling as factors promoting viral oncolysis
Although interferon-non-responsive cancer cells may have acquired a growth/survival advantage over other cells, they are more susceptible to viral infections, therefore, they are probably more sensitive to oncolytic virotherapy.
Our aim was to analyze correlation between defects in antiviral signaling pathway of different cancer cell lines and their susceptibility to oncolytic viruses. We identified ability of cancer cells to respond to treatment with interferon. It was shown that among different groups of cancer exist IFN sensitive and completely resistant cancer cell lines. Then we assessed ability of cancer cells to produce IFN in response to induction with virus. There was also a significant difference between amounts of secreted IFN: some lines exhibited production of IFN on comparable to normal cells level, while others had undetectably low, if any, quantity. We also established correlation between identified defects and susceptibility of cancer cells to oncolytic viruses.